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Acnezine Treatment for Acne in Pregnancy Plan Before You Get PregnantIf you are planning to get pregnant, it is important to discuss your acne treatments with your doctor. Many of these can harm the unborn baby. These include tetracycline antibiotics, oral isotretinoin (Roaccutane, Accutane) and topical retinoids (tretinoin, isotretinoin and adapalene). Erythromycin is the only antibiotic regarded as being safe in pregnancy, but it may not be very effective as many skin bacteria are now resistant to it. However, it's probably better to avoid all medications if possible.